Publications

Theranostics-9-July-2023

Click-to-Release: Cleavable Radio-immunoimaging with 89Zr-DFO-Trans-Cyclooctene-Trastuzumab Increases Tumor-to-Blood Ratio

Theranostics, 9 July 2023

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A Concise Synthetic Approach to Highly Reactive Click-to-Release Trans- Cyclooctene Linkers

Chemistry – A European Journal, 24 May 2023

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Bioorthogonal chemistry

Nature Reviews Methods Primers, 15 April 2021

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Bioorthogonal Tetrazine Carbamate Cleavage by Highly Reactive trans-Cyclooctene

Journal of the American Chemical Society, 26 May 2020

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Click-to-Release from trans-Cyclooctenes: Mechanistic Insights and Expansion of Scope from Established Carbamate to Remarkable Ether Cleavage

Angewandte Chemie International Edition, 10 May 2018

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Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice

Nature Communications, 04 May 2018

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Triggered Drug Release from an Antibody–Drug Conjugate Using Fast “Click-to-Release” Chemistry in Mice

Bioconjugate Chemistry, 15 June 2016 

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CC49 diabody pretargeting using click chemistry in vivo

Journal of Nuclear Medicine, 01 September 2015

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Pretargeted imaging using bioorthogonal chemistry in mice

Current Opinion in Chemical Biology, 19 August 2014

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Trans-Cyclooctene Tag with Improved Properties for Tumor Pretargeting with the Diels–Alder Reaction

Molecular Pharmaceutics, 31 July 2014

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Click to Release: Instantaneous Doxorubicin Elimination upon Tetrazine Ligation

Angewandte Chemie International Edition, 26 November 2013

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Diels–Alder Reaction for Tumor Pretargeting: In Vivo Chemistry Can Boost Tumor Radiation Dose Compared with Directly Labeled Antibody

Journal of Nuclear Medicine, 03 October, 2013

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Highly Reactive trans-Cyclooctene Tags with Improved Stability for Diels–Alder Chemistry in Living Systems

Bioconjugate Chemistry, 01 June 2013

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Evaluation of strained alkynes for Cu-free click reaction in live mice

Nuclear Medicine and Biology,  4 February 2013

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Synthesis of Phosphine and Antibody–Azide Probes for in Vivo Staudinger Ligation in a Pretargeted Imaging and Therapy Approach

Bioconjugate Chemistry, 22 August 22 2011

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In Vivo Chemistry for Pretargeted Tumor Imaging in Live Mice

Angewandte Chemie International Edition, 20 April 2010

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A Doxorubicin Prodrug Activated by the Staudinger Reaction

Bioconjugate Chemistry, February 14, 2008

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