Publications
Click-to-Release for Controlled Immune Cell Activation: Tumor-Targeted Unmasking of an IL12 Prodrug
Pharmaceuticals
16 September 2025
Preclinical development of TGW101, a first in class click-cleavable ADC with MMAE against non-internalizing pan-carcinoma marker TAG72
AACR Annual Meeting,
25-30 April 2025
Click-to-release for controlled immune cell activation: tumor-targeted unmasking of an IL12 prodrug in vivo
AACR Annual Meeting,
25-30 April 2025
Toward realization of bioorthogonal chemistry in the clinic
Topics in Current Chemistry,
5 March 2025
Ortho-functionalized pyridinyl-tetrazines break the inverse correlation between click reactivity and cleavage yields in click-to-release chemistry
Communications Chemistry, 19 December 2024
Click-to-Release: Cleavable Radio-immunoimaging with 89Zr-DFO-Trans-Cyclooctene-Trastuzumab Increases Tumor-to-Blood Ratio
Theranostics, 9 July 2023
A Concise Synthetic Approach to Highly Reactive Click-to-Release Trans- Cyclooctene Linkers
Chemistry – A European Journal, 24 May 2023
Bioorthogonal Tetrazine Carbamate Cleavage by Highly Reactive trans-Cyclooctene
Journal of the American Chemical Society, 26 May 2020
Click-to-Release from trans-Cyclooctenes: Mechanistic Insights and Expansion of Scope from Established Carbamate to Remarkable Ether Cleavage
Angewandte Chemie International Edition, 10 May 2018
Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice
Nature Communications, 04 May 2018
Triggered Drug Release from an Antibody–Drug Conjugate Using Fast “Click-to-Release” Chemistry in Mice
Bioconjugate Chemistry, 15 June 2016
CC49 diabody pretargeting using click chemistry in vivo
Journal of Nuclear Medicine, 01 September 2015
Pretargeted imaging using bioorthogonal chemistry in mice
Current Opinion in Chemical Biology, 19 August 2014
Trans-Cyclooctene Tag with Improved Properties for Tumor Pretargeting with the Diels–Alder Reaction
Molecular Pharmaceutics, 31 July 2014
Click to Release: Instantaneous Doxorubicin Elimination upon Tetrazine Ligation
Angewandte Chemie International Edition, 26 November 2013
Diels–Alder Reaction for Tumor Pretargeting: In Vivo Chemistry Can Boost Tumor Radiation Dose Compared with Directly Labeled Antibody
Journal of Nuclear Medicine, 03 October, 2013
Highly Reactive trans-Cyclooctene Tags with Improved Stability for Diels–Alder Chemistry in Living Systems
Bioconjugate Chemistry, 01 June 2013
Evaluation of strained alkynes for Cu-free click reaction in live mice
Nuclear Medicine and Biology, 4 February 2013
Synthesis of Phosphine and Antibody–Azide Probes for in Vivo Staudinger Ligation in a Pretargeted Imaging and Therapy Approach
Bioconjugate Chemistry, 22 August 22 2011
In Vivo Chemistry for Pretargeted Tumor Imaging in Live Mice
Angewandte Chemie International Edition, 20 April 2010
A Doxorubicin Prodrug Activated by the Staudinger Reaction
Bioconjugate Chemistry, February 14, 2008
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