As the pioneers of Click-to-Release technology, we use in vivo click chemistry to increase efficacy & decrease toxicity across several systemic treatment modalities.

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Team works

We are led by a seasoned team of researchers, oncologists, and biotech business builders, all motivated by a desire to bring safe, effective treatments to patients.

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Click-to-Release Technology

We have built a leading technology that enables controlled drug release induced by an in vivo click reaction with a trigger molecule with the aim to increase the therapeutic window and utility of potent systemic therapies. Key applications include the on-target activation of antibody-drug conjugates (ADCs) and immunomodulators in the tumor microenvironment, as well as the off-target deactivation of unwanted circulating radiopharmaceuticals.

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Expanding the Therapeutic Potential of ADCs

Conventional ADCs are limited to suitable internalizing targets, which are not necessarily expressed by every cancer type and cancer cell. We are leveraging our Click-to-Release approach to expand the ADC target scope to non- or poorly internalizing receptors and markers. It also enables controlled drug release with a broad bystander effect that makes it possible to kill tumors with heterogenous target expression. Our lead program, TGW101, is a click-cleavable ADC targeting TAG72, a clinically validated non-internalizing target that is widely expressed in solid tumors, but which has so far remained out of reach of current ADC therapies.

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News

June 22, 2023
Financing round led by Ysios Capital and Gilde Healthcare with participation from Novartis Venture Fund, New Enterprise Associates, and Lightstone Ventures Unique Click-to-Release platform enables on-target activation of antibody-drug conjugates …
October 5, 2022
Tagworks congratulates Carolyn Bertozzi, Morten Meldal and Barry Sharpless with winning the Nobel Prize in Chemistry 2022 for the development of click chemistry and bioorthogonal chemistry ! Their discoveries made …
October 5, 2022
Carolyn R. Bertozzi, Morten Meldal, and K. Barry Sharpless receive prize for their work on reactions that quickly link molecules and the application of the reactions in living cells Three …

Curious about what we do? Get in touch!

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Contact
T +31 85 800 8550
info@tagworkspharma.com

Address
Tagworks Pharmaceuticals BV
Toernooiveld 1
6525 ED  Nijmegen
The Netherlands

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